Immunotoxins are hybrid molecules formed by coupling antibody molecules to powerful toxins of plant or bacterial origin. In experimental systems, immunotoxins have been found to kill cancer cells with great potency and specificity. This article reviews the current status of immunotoxins and some of the problems that have to be overcome before they can be used to treat human malignant disease.

In temporal binding, the temporal interval between one event and another, occurring some time later, is subjectively compressed. We discuss two ways in which temporal binding has been conceptualized. In studies showing temporal binding between a voluntary action and its causal consequences, such binding is typically interpreted as providing a measure of an implicit or pre-reflective “sense of agency”. However, temporal binding has also been observed in contexts not involving voluntary action, but only the passive observation of a cause-effect sequence. (...) In those contexts, it has been interpreted as a top-down effect on perception reflecting a belief in causality. These two views need not be in conflict with one another, if one thinks of them as concerning two separate mechanisms through which temporal binding can occur. In this paper, we explore an alternative possibility: that there is a unitary way of explaining temporal binding both within and outside the context of voluntary action as a top-down effect on perception reflecting a belief in causality. Any such explanation needs to account for ways in which agency, and factors connected with agency, have been shown to affect the strength of temporal binding. We show that principles of causal inference and causal selection already familiar from the literature on causal learning have the potential to explain why the strength of people’s causal beliefs can be affected by the extent to which they are themselves actively involved in bringing about events, thus in turn affecting binding. (shrink)

Although it has long been known that time is a cue to causation, recent work with adults has demonstrated that causality can also influence the experience of time. In causal reordering (Bechlivanidis & Lagnado, 2013, 2016) adults tend to report the causally consistent order of events, rather than the correct temporal order. However, the effect has yet to be demonstrated in children. Across four pre-registered experiments, 4- to 10-year-old children (N=813) and adults (N=178) watched a 3-object Michotte-style ‘pseudocollision’. While in (...) the canonical version of the clip object A collided with B, which then collided with object C (order: ABC), the pseudocollision involved the same spatial array of objects but featured object C moving before object B (order: ACB), with no collision between B and C. Participants were asked to judge the temporal order of events and whether object B collided with C. Across all age groups, participants were significantly more likely to judge that B collided with C in the 3-object pseudocollision than in a 2-object control clip (where clear causal direction was lacking), despite the spatiotemporal relations between B and C being identical in the two clips (Experiments 1—3). Collision judgements and temporal order judgements were not entirely consistent, with some participants—particularly in the younger age range—basing their temporal order judgements on spatial rather than temporal information (Experiment 4). We conclude that in both children and adults, rather than causal impressions being determined only by the basic spatial-temporal properties of object movement, schemata are used in a top-down manner when interpreting perceptual displays. (shrink)

There are several branches of ethics. Clinical ethics, the one closest to medical decisionmaking, can be seen as a branch of medicine itself. In this view, clinical ethics is a unitary hermeneutics. Its rule is a guideline for unifying other theories of ethics in conjunction with the clinical context. Put another way, clinical ethics interprets the clinical situation in light of a balance of other values that, while guiding the decisionmaking process, also contributes to the very weighting of those values. (...) The case itself originates ideas, not only about which value ought to predominate in its resolution, but also provides the origin of clinical rules that can be used in other cases. These are interpretive rules. Some examples of these rules are presented as well. (shrink)

This book, in language accessible to the general reader, investigates twelve of the most notorious, most interesting, and most instructive episodes involving the interaction between science and Christianity, aiming to tell each story in its historical specificity and local particularity. Among the events treated in When Science and Christianity Meet are the Galileo affair, the seventeenth-century clockwork universe, Noah's ark and flood in the development of natural history, struggles over Darwinian evolution, debates about the origin of the human species, and (...) the Scopes trial. Readers will be introduced to St. Augustine, Roger Bacon, Pope Urban VIII, Isaac Newton, Pierre-Simon de Laplace, Carl Linnaeus, Charles Darwin, T. H. Huxley, Sigmund Freud, and many other participants in the historical drama of science and Christianity. (shrink)

In this paper dedicated to Carlos Alchourrón, we review an issue that emerged only after his death in 1996, but would have been of great interest to him: To what extent do the formal operations of AGM belief change respect criteria of relevance? A natural criterion was proposed in 1999 by Rohit Parikh, who observed that the AGM model does not always respect it. We discuss the pros and cons of this criterion, and explain how the AGM account may be (...) refined, if we so desire, so that it is always respected. En este trabajo dedicado a Carlos Alchourrón consideramos un problema que surgió recién después de su muerte en 1996 pero que seguramente habría sido de gran interés para él: ¿hasta dónde las operaciones formales sobre el cambio de creencias de AGM respetan el criterio de relevancia? Un criterio natural ha sido propuesto en 1999 por Rohit Parikh quien asimismo observó que el modelo AGM no siempre lo respeta. Nosotros discutimos los pros y los contras de este criterio y explicamos cómo podría refinarse AGM para que, si así lo deseáramos, lo respetara siempre. (shrink)

The concept of relevance between classical propositional formulae, defined in terms of letter-sharing, has been around for a very long time. But it began to take on a fresh life in 1999 when it was reconsidered in the context of the logic of belief change. Two new ideas appeared in independent work of Odinaldo Rodrigues and Rohit Parikh. First, the relation of relevance was considered modulo the belief set under consideration, Second, the belief set was put in a canonical form, (...) known as its finest splitting. In this paper we explain these ideas; relate the approaches of Rodrigues and Parikh to each other; and briefly report some recent results of Kourousias and Makinson on the extent to which AGM belief change operations respect relevance. Finally we suggest a further refinement of the notion of relevance by introducing a parameter that allows one to take epistemic as well as purely logical components into account. -/- A version of this was published in the /Journal of Applied Logic/ (Elsevier). (shrink)

We define and examine a notion of logical friendliness, which is a broadening of the familiar notion of classical consequence. The concept is tudied first in its simplest form, and then in a syntax-independent version, which we call sympathy. We also draw attention to the surprising number of familiar notions and operations with which it makes contact, providing a new light in which they may be seen.

Ten years of educational reform have not brought dramatic improvements. In Ideology and Educational Reform, David Paris traces the underlying ideological problems that make genuine reform difficult. These include different and often conflicting beliefs concerning the proper role of public education as well as the public's natural ambivalence about schools as government agencies.Paris describes three major themes in public education—common school, human capital, and clientelism. He critically evaluates current policies and proposed reforms associated with each of these topics, including (...) moral education, the school-economy relationship, school choice, and the delivery of social services. Paris proposes better ways for dealing with ideological problems in school practice, and he suggests appropriate directions for policy reform. (shrink)

This is the first book-length study of the development of civility in Chinese societies. Although some social scientists and political philosophers have discussed civility, none has defined it as an analytical tool to systematically measure attitudes and behavior, and few have applied it to a non-Western society. By comparing the development of civility in mainland China and Taiwan, Civility and Its Development: The Experiences of China and Taiwan analyzes the social conditions needed for civility to become established in a society. (...) Schak argues that the attempts to impose civility top-down from the state are ineffective. Civility appeared in Taiwan only after state efforts to impose it ceased at the end of the 1980s when Taiwan began to democratize, and the PRC government civility campaigns have so far had only limited success. The book concludes with an examination of various differences between Taiwan and the PRC relevant to Taiwan’s having become a society with civility while the PRC still encounters difficulties in doing so. The essential factor in developing civility in Taiwan, Schak contends, was its evolution from a place composed of myriad small, inward-looking communities to a society in which everyone shares a strong identity and civic consciousness, and people consider others as fellow members, not anonymous strangers. “This book represents the most thorough review of what social scientists once called ‘the civilizing process’ in Chinese society. David C. Schak builds on the earlier studies on this issue and goes well beyond the established literature.” —James Watson, Fairbank Professor of Chinese Society and Professor of Anthropology, Emeritus, Harvard University “This is a topic that people talk about all the time, and David C. Schak draws a lot of material together in a systematic and comprehensive way that can stimulate important discussions beyond the academy.” —Thomas Gold, Professor of Sociology, University of California, Berkeley. (shrink)

Amor Dei, “love of God” raises three questions: How do we know God is love? How do we experience love of God? How free are we to love God? This book presents three kinds of love, worldly, spiritual, and divine to understand God’s love. The work begins with Augustine’s Confessions highlighting his Manichean and Neoplatonic periods before his conversion to Christianity. Augustine’s confrontation with Pelagius anticipates the unresolved disputes concerning God’s love and free will. In the sixteenth-century the Italian humanist, (...) Gasparo Contarini introduces the notion of “divine amplitude” to demonstrate how God’s goodness is manifested in the human agent. Pierre de Bérulle, Guillaume Gibieuf, and Nicolas Malebranche show connections with Contarini in the seventeenth-century controversies relating free will and divine love. In response to the free will dispute, the Scottish philosopher, William Chalmers, offers his solution. Cornelius Jansen relentlessly asserts his anti-Pelagian interpretation of Augustine stirring up more controversy. John Norris, Malebranche’s English disciple, exchanges his views with Mary Astell and Damaris Masham. In the tradition of Cambridge Platonism, Ralph Cudworth conveys a God who “sweetly governs.” The organization of sections represents the love of God in ascending-descending movements demonstrating that, “human love is inseparable from divine love.”. (shrink)

Technology's contribution to economic growth and competitiveness has been the subject of vigorous debate in recent years. This book demonstrates the importance of a historical perspective in understanding the role of technological innovation in the economy. The authors examine key episodes and institutions in the development of the U.S. research system and in the development of the research systems of other industrial economies. They argue that the large potential contributions of economics to the understanding of technology and economic growth have (...) been constrained by the narrow theoretical framework employed within neoclassical economies. A richer framework, they believe, will support a more fruitful dialogue among economists, policymakers, and managers on the organization of public and private institutions for innovation. David Mowery is Associate Professor of Business and Public Policy at the School of Business Administration, University of California, Berkeley. Nathan S. Rosenberg is Fairleigh Dickinson Professor of Economics at Stanford University. He is the author of Inside the Black Box: Technology and Economics. (shrink)

Field and Hineline have shown how pervasive and insidious is the tendency to make dispositional attributions, even among those who criticize the practice, and they identify a bias for models of contiguous causation as one reason for this tendency. They argue that order can be found at multiple scales of analysis and that in some cases a translation to a model of contiguous causation is impossible. I suggest that pragmatic considerations are sufficient to justify a particular scale of analysis and (...) observe that behavioral principles are fundamentally extended in time. However, I argue that accounting for variance is the goal of science; when events at one level are indeed mediated by those at another, more of the variance can be accounted for by considering both, and there is no principled reason for considering only one. (shrink)

This overview of the "sister arts" of the nineteenth century by younger scholars in art history, literature, and American studies presents a startling array of perspectives on the fundamental role played by images in culture and society. Drawing on the latest thinking about vision and visuality as well as on recent developments in literary theory and cultural studies, the contributors situate paintings, sculpture, monument art, and literary images within a variety of cultural contexts. The volume offers fresh and sometimes extended (...) discussions of single works as well as reevaluations of artistic and literary conventions and analyses of the economic, social, and technological forces that gave them shape and were influenced by them in turn. A wide range of figures are significantly reassessed, including the painters Charles Willson Peale, Washington Allston, Thomas Cole, George Caleb Bingham, Fitz Hugh Lane, and Mary Cassatt, and such writers as James Fenimore Cooper, Nathaniel Hawthorne, Henry David Thoreau, and William Dean Howells. One overarching theme to emerge is the development of an American national subjectivity as it interacted with the transformation of a culture dominated by religious values to one increasingly influenced by commercial imperatives. The essays probe the ways in which artists and writers responded to the changing conditions of the cultural milieu as it was mediated by such factors as class and gender, modes of perception and representation, and conflicting ideals and realities. (shrink)

Like most other sciences, behavior analysis adopts an assumption of uniformity, namely that principles discovered under controlled conditions apply outside the laboratory as well. Since the boundary between public and private depends on the vantage point of the observer, observability is not an inherent property of behavior. From this perspective, private events are assumed to enter into the same orderly relations as public behavior, and the distinction between public and private events is merely a practical one. Private events play no (...) role in the experimental analysis of behavior, but they permit us to make sense of many commonplace phenomena where controlled observation is impossible but unsystematic data are available. Such interpretive exercises serve both to guide research and to displace occult explanations. (shrink)

A discussion of the connections and differences between completeness and representation theorems in logic, with examples drawn from classical and modal logic, the logic of friendliness, and nonmonotonic reasoning.

The Supreme Court frequently uses two tools to gather information about which cases to hear following a petition for writ of certiorari: the call for response and the call for the views of the Solicitor General. To date, there has been no empirical analysis of how the Supreme Court deploys these tools and little qualitative study. This Article fills in basic gaps in the literature by providing concrete answers to common questions regarding these two tools and offers detailed analysis of (...) how and why states, private parties, and the United States (through the Solicitor General) respond to petitions. In addition, the Article provides much-needed data for litigators and litigants to be able to estimate the probability of their case being heard by the Court, and provides insight on how to react when the Court calls for a response or calls for the views of the Solicitor General. To reach these conclusions, the Article relies on detailed, quantitative analysis of a novel, 30,000-petition dataset, as well as interviews with top Supreme Court litigators, former Supreme Court clerks, and former staff of the Clerk’s office. (shrink)

Moral capacity is an important feature of what it means to be human. In this volume, the contributors have taken on the daunting task of trying to distinguish between legal and moral capacity. This distinction is difficult at times for clinicians, philosophers and legal scholars alike. Part of the challenge of defining moral capacity lies in the difficulty of adequately categorizing it. For this reason, the editors have chosen to divide the book into three parts. The first looks at the (...) concepts involved in the discussion of moral capacity; the second considers the role of moral capacity in the lives of professionals; and the final part reflects on case studies of moral capacity or incapacity illustrating the challenge that moral capacity presents - its definition lying between two seemingly incommensurable models, those of the threshold and continuum. This volume takes a multidisciplinary approach to the subject, and ties the disciplines of medicine, philosophy and law into the health context. It will be of interest to medical health professionals as well as researchers working in the areas of philosophy and law. (shrink)

As an introduction to this issue, I argue that the concept of autonomy is clearly important for many of the freedoms we enjoy. The problem in medicine with its use lies in interpreting the concept with respect to the impact of disease on persons, the models of medicine we employ, and the settings in which the problems arise. A short statement about the major points of the authors collected in this issue concludes the editorial.

We investigate introduction and elimination rules for truth-functional connectives, focusing on the general questions of the existence, for a given connective, of at least one such rule that it satisfies, and the uniqueness of a connective with respect to the set of all of them. The answers are straightforward in the context of rules using general set/set sequents of formulae, but rather complex and asymmetric in the restricted (but more often used) context of set/formula sequents, as also in the intermediate (...) set/formula-or-empty context. (shrink)

"Dr. Rubin has brought cognitive psychology into a wholly unprecedented dialogue with studies in oral tradition. The result is a truly new perspective on memory and the processes of oral tradition." --John Miles Foley, University of Missouri.

Unit 4. Goodman, D.C. God and nature in the philosophy of Descartes. --Unit 5. Brooke, J.H. Newton and the mechanistic universe.

Reviews the connections between different kinds of nonmonotonic logic and the general idea of varying degrees of belief.

Relevance logic is ordinarily seen as a subsystem of classical logic under the translation that replaces arrows by horseshoes. If, however, we consider the arrow as an additional connective alongside the horseshoe, then another perspective emerges: the theses of relevance logic, specifically the system R, may also be seen as the output of a conservative extension of the relation of classical consequence. We describe two ways in which this may be done. One is by defining a suitable closure relation out (...) of the set of theses of relevance logic; the other is by adding to the usual natural deduction system for it further rules with ‘projective constraints’, whose application restricts the subsequent application of other rules. The significance of the two constructions is also discussed. (shrink)

Applying general and statistical knowledge to individuals is difficult either on epidemiological or epistemological grounds. This paper examines these difficulties from the perspective of computer registers of epidemiological data.